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Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
Amyloid-β peptide (Aβ) accumulation in the brain is an early, toxic event in the pathogenesis of Alzheimer's disease (AD). Aβ is produced by proteolytic processing of a transmembrane protein, β-amyloid precursor protein (APP), by β- and γ-secretases. Mounting evidence has demonstrated that alte...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1563464/ https://www.ncbi.nlm.nih.gov/pubmed/16930455 http://dx.doi.org/10.1186/1750-1326-1-8 |