Use of cloned and expressed human liver UDP-glucuronosyltransferases for analysis of drug glucuronide formation and assessment of drug toxicity.

Five cloned human hepatic UDP-glucuronosyltransferase (UGT) cDNAs were stably expressed in tissue culture cell lines. More than 100 drugs and xenobiotics were used as substrates for glucuronidation catalyzed by the cloned human transferases to determine the chemical structures accepted as substrates...

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Detalles Bibliográficos
Autores principales: Burchell, B, Ebner, T, Baird, S, Bin Senafi, S, Clarke, D, Brierley, C, Sutherland, L
Formato: Texto
Lenguaje:English
Publicado: 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566788/
https://www.ncbi.nlm.nih.gov/pubmed/7698078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566788/
https://www.ncbi.nlm.nih.gov/pubmed/7698078

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