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Characterization and expression of hepatic sulfotransferase involved in the metabolism of N-substituted aryl compounds.

An aryl sulfotransferase, whose cDNA was isolated from the rat liver library, was found to catalyze bioactivation of minoxidil through N-O-sulfation and N-sulfation of a carcinogenic heterocyclic amine, IQ, by expression in COS-1 cells. cDNA of a human ortholog also was isolated and characterized as...

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Detalles Bibliográficos
Autores principales: Yamazoe, Y, Ozawa, S, Nagata, K, Gong, D W, Kato, R
Formato: Texto
Lenguaje:English
Publicado: 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566861/
https://www.ncbi.nlm.nih.gov/pubmed/7889867