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Hemoglobin binding of arylamines and nitroarenes: molecular dosimetry and quantitative structure-activity relationships.
N-Oxidation and nitroreduction to yield N-hydroxyarylamines are metabolic steps that are crucial for the genotoxic properties of aromatic amines and nitroarenes, respectively. N-Hydroxyarylamines can form adducts with DNA, tissue proteins, and the blood proteins albumin and hemoglobin in a dose-depe...
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| Formato: | Texto |
| Lenguaje: | English |
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1994
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566868/ https://www.ncbi.nlm.nih.gov/pubmed/7889861 |