Induction of hepatocellular carcinoma in nonhuman primates by the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline.

The heterocyclic aromatic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was evaluated for carcinogenic effects in macaques, primarily cynomolgus monkeys. IQ was administered by gavage five times a week at doses of 10 or 20 mg/kg. IQ induced hepatocellular carcinoma in 55% of the animals at the...

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Detalles Bibliográficos
Autores principales: Adamson, R H, Takayama, S, Sugimura, T, Thorgeirsson, U P
Formato: Texto
Lenguaje:English
Publicado: 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567205/
https://www.ncbi.nlm.nih.gov/pubmed/8033850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567205/
https://www.ncbi.nlm.nih.gov/pubmed/8033850

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