Induction of internucleosomal DNA fragmentation by carcinogenic chromate: relationship to DNA damage, genotoxicity, and inhibition of macromolecular synthesis.

Hexavalent chromium (Cr) compounds are respiratory carcinogens in humans and animals. Treatment of Chinese hamster ovary cells with 150 and 300 microM sodium chromate (Na2CrO4) for 2 hr decreased colony-forming efficiency by 46 and 92%, respectively. These treatments induced dose-dependent internucl...

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Detalles Bibliográficos
Autores principales: Manning, F C, Blankenship, L J, Wise, J P, Xu, J, Bridgewater, L C, Patierno, S R
Formato: Texto
Lenguaje:English
Publicado: 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567430/
https://www.ncbi.nlm.nih.gov/pubmed/7843091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567430/
https://www.ncbi.nlm.nih.gov/pubmed/7843091

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