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Role of prostaglandin-H synthase in mediating genotoxic and carcinogenic effects of estrogens.
Diethylstilbestrol (DES) has been found to be oxidized in Syrian hamster embryo (SHE) cells by prostaglandin-H synthase (PGH synthase). It is hypothesized that PGH synthase mediates adverse effects of DES and other carcinogenic estrogens such as induction of neoplastic transformation and genotoxicit...
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| Formato: | Texto |
| Lenguaje: | English |
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1990
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568007/ https://www.ncbi.nlm.nih.gov/pubmed/2125558 |