Ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate teratology studies.

An inhalation teratology study was conducted in rats at 10, 50 and 250 ppm ethylene glycol monoethyl ether (EGEE) and in rabbits at 10, 50 and 175 ppm EGEE. This study was designed to supplement a study conducted for NIOSH which showed teratogenic effects in rats at 200 ppm EGEE and in rabbits at ab...

Descripción completa

Detalles Bibliográficos
Autor principal: Doe, J E
Formato: Texto
Lenguaje:English
Publicado: 1984
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568288/
https://www.ncbi.nlm.nih.gov/pubmed/6499816
_version_ 1782129980783722496
author Doe, J E
author_facet Doe, J E
author_sort Doe, J E
collection PubMed
description An inhalation teratology study was conducted in rats at 10, 50 and 250 ppm ethylene glycol monoethyl ether (EGEE) and in rabbits at 10, 50 and 175 ppm EGEE. This study was designed to supplement a study conducted for NIOSH which showed teratogenic effects in rats at 200 ppm EGEE and in rabbits at about 160 ppm EE. In this study, EGEE was found not to cause teratogenic effects at concentrations up to and including 250 ppm in rats and 50 ppm in rabbits, while 175 ppm EGEE was considered to be a marginal effect level for teratogenic effects in rabbits. Fetotoxicity was observed at 250 ppm EGEE and possibly at 50 ppm EGEE in rats. An inhalation teratology study using ethylene glycol monoethyl ether acetate (EGEEA) has been conducted in rabbits at 25, 100 and 400 ppm. There was evidence of teratogenicity (vertebral malformations) at 400 ppm EGEEA and slight fetotoxicity at 100 ppm; 25 ppm was a no effect level.
format Text
id pubmed-1568288
institution National Center for Biotechnology Information
language English
publishDate 1984
record_format MEDLINE/PubMed
spelling pubmed-15682882006-09-18 Ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate teratology studies. Doe, J E Environ Health Perspect Research Article An inhalation teratology study was conducted in rats at 10, 50 and 250 ppm ethylene glycol monoethyl ether (EGEE) and in rabbits at 10, 50 and 175 ppm EGEE. This study was designed to supplement a study conducted for NIOSH which showed teratogenic effects in rats at 200 ppm EGEE and in rabbits at about 160 ppm EE. In this study, EGEE was found not to cause teratogenic effects at concentrations up to and including 250 ppm in rats and 50 ppm in rabbits, while 175 ppm EGEE was considered to be a marginal effect level for teratogenic effects in rabbits. Fetotoxicity was observed at 250 ppm EGEE and possibly at 50 ppm EGEE in rats. An inhalation teratology study using ethylene glycol monoethyl ether acetate (EGEEA) has been conducted in rabbits at 25, 100 and 400 ppm. There was evidence of teratogenicity (vertebral malformations) at 400 ppm EGEEA and slight fetotoxicity at 100 ppm; 25 ppm was a no effect level. 1984-08 /pmc/articles/PMC1568288/ /pubmed/6499816 Text en
spellingShingle Research Article
Doe, J E
Ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate teratology studies.
title Ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate teratology studies.
title_full Ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate teratology studies.
title_fullStr Ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate teratology studies.
title_full_unstemmed Ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate teratology studies.
title_short Ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate teratology studies.
title_sort ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate teratology studies.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568288/
https://www.ncbi.nlm.nih.gov/pubmed/6499816
work_keys_str_mv AT doeje ethyleneglycolmonoethyletherandethyleneglycolmonoethyletheracetateteratologystudies