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Mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis.

The mechanism of the trichomonicidal activity of metronidazole and other 5-nitroimidazoles appears to depend on the ferredoxin-mediated reduction of their nitro group, with generation of a reactive metabolite or metabolites which interact with DNA leading to a subsequent inhibition of nucleic acid a...

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Detalles Bibliográficos
Autores principales: Moreno, S N, Docampo, R
Formato: Texto
Lenguaje:English
Publicado: 1985
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568619/
https://www.ncbi.nlm.nih.gov/pubmed/3830698