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Polyclonal antibodies to quantitate cis-diamminedichloroplatinum(II)--DNA adducts in cancer patients and animal models.
cis-Diamminedichloroplatinum (II) (cis-DDP), the antitumor drug, is cytotoxic in vitro primarily by binding to DNA and disrupting its normal functions. We have studied cis-DDP modification of DNA in nucleated peripheral blood cells (buffy coat cells) of testicular and ovarian cancer patients receivi...
Autores principales: | Poirier, M C, Reed, E, Zwelling, L A, Ozols, R F, Litterst, C L, Yuspa, S H |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
1985
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568668/ https://www.ncbi.nlm.nih.gov/pubmed/4085451 |
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