Chemical modification of DNA with muta-carcinogens. II. Base sequence-specific binding to DNA of 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1).

2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) binds covalently to DNA after metabolic activation to give 2-(C8-guanyl)amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Gua-Glu-P-1). The importance of the intercalative ability of the Glu-P-1 skeleton into DNA base pairs...

Descripción completa

Detalles Bibliográficos
Autores principales: Hashimoto, Y, Shudo, K
Formato: Texto
Lenguaje:English
Publicado: 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568680/
https://www.ncbi.nlm.nih.gov/pubmed/3910418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568680/
https://www.ncbi.nlm.nih.gov/pubmed/3910418

Ejemplares similares