Direct alkylation of calf thymus DNA by acrylonitrile. Isolation of cyanoethyl adducts of guanine and thymine and carboxyethyl adducts of adenine and cytosine.

Reaction of the rodent carcinogen acrylonitrile (AN) at pH 7.0 for 10 and/or 40 days with 2'-deoxyadenosine (dAdo), 2'-deoxycytidine (dCyd), 2'-deoxyguanosine (dGuo), 2'-deoxyinosine (dIno), and thymidine (dThd) resulted in the formation of cyanoethyl and carboxyethyl adducts. Th...

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Detalles Bibliográficos
Autores principales: Solomon, J J, Segal, A
Formato: Texto
Lenguaje:English
Publicado: 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568706/
https://www.ncbi.nlm.nih.gov/pubmed/4085427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568706/
https://www.ncbi.nlm.nih.gov/pubmed/4085427

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