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Wnt/Wingless signaling through β-catenin requires the function of both LRP/Arrow and frizzled classes of receptors
BACKGROUND: Wnt/Wingless (Wg) signals are transduced by seven-transmembrane Frizzleds (Fzs) and the single-transmembrane LDL-receptor-related proteins 5 or 6 (LRP5/6) or Arrow. The aminotermini of LRP and Fz were reported to associate only in the presence of Wnt, implying that Wnt ligands form a tri...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC156895/ https://www.ncbi.nlm.nih.gov/pubmed/12729465 http://dx.doi.org/10.1186/1471-2121-4-4 |