Toxicity of vinyl chloride and poly(vinyl chloride): a critical review.

In 1974, vinyl chloride (VC) was first reported in the open scientific literature to induce angiosarcoma of the liver both in humans and in animals. Additional research has now demonstrated the carcinogenicity of VC to other organs and at lower concentrations. The target organs for VC now clearly in...

Descripción completa

Detalles Bibliográficos
Autor principal: Wagoner, J K
Formato: Texto
Lenguaje:English
Publicado: 1983
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569348/
https://www.ncbi.nlm.nih.gov/pubmed/6360677
_version_ 1782130184476950528
author Wagoner, J K
author_facet Wagoner, J K
author_sort Wagoner, J K
collection PubMed
description In 1974, vinyl chloride (VC) was first reported in the open scientific literature to induce angiosarcoma of the liver both in humans and in animals. Additional research has now demonstrated the carcinogenicity of VC to other organs and at lower concentrations. The target organs for VC now clearly include the liver, brain and the lung, and probably the lymphohematopoietic system. The evidence for a carcinogenic risk has been extended to jobs associated with poly(vinyl chloride) exposure. Cases of liver angiosarcoma have been reported among individuals employed in PVC fabrication facilities and an epidemiological study has demonstrated a significant association between exposure to PVC dust and the risk of lung cancer mortality. Cases of angiosarcoma of the liver also have been reported among individuals living in near proximity to vinyl chloride-poly(vinyl chloride) plants. An association between PVC dust and pneumoconiosis also has been demonstrated. On the basis of findings, prudent control of PVC dust in the industrial setting is indicated.
format Text
id pubmed-1569348
institution National Center for Biotechnology Information
language English
publishDate 1983
record_format MEDLINE/PubMed
spelling pubmed-15693482006-09-18 Toxicity of vinyl chloride and poly(vinyl chloride): a critical review. Wagoner, J K Environ Health Perspect Research Article In 1974, vinyl chloride (VC) was first reported in the open scientific literature to induce angiosarcoma of the liver both in humans and in animals. Additional research has now demonstrated the carcinogenicity of VC to other organs and at lower concentrations. The target organs for VC now clearly include the liver, brain and the lung, and probably the lymphohematopoietic system. The evidence for a carcinogenic risk has been extended to jobs associated with poly(vinyl chloride) exposure. Cases of liver angiosarcoma have been reported among individuals employed in PVC fabrication facilities and an epidemiological study has demonstrated a significant association between exposure to PVC dust and the risk of lung cancer mortality. Cases of angiosarcoma of the liver also have been reported among individuals living in near proximity to vinyl chloride-poly(vinyl chloride) plants. An association between PVC dust and pneumoconiosis also has been demonstrated. On the basis of findings, prudent control of PVC dust in the industrial setting is indicated. 1983-10 /pmc/articles/PMC1569348/ /pubmed/6360677 Text en
spellingShingle Research Article
Wagoner, J K
Toxicity of vinyl chloride and poly(vinyl chloride): a critical review.
title Toxicity of vinyl chloride and poly(vinyl chloride): a critical review.
title_full Toxicity of vinyl chloride and poly(vinyl chloride): a critical review.
title_fullStr Toxicity of vinyl chloride and poly(vinyl chloride): a critical review.
title_full_unstemmed Toxicity of vinyl chloride and poly(vinyl chloride): a critical review.
title_short Toxicity of vinyl chloride and poly(vinyl chloride): a critical review.
title_sort toxicity of vinyl chloride and poly(vinyl chloride): a critical review.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569348/
https://www.ncbi.nlm.nih.gov/pubmed/6360677
work_keys_str_mv AT wagonerjk toxicityofvinylchlorideandpolyvinylchlorideacriticalreview