Use of a Physiologically Based Pharmacokinetic Model for Rats to Study the Influence of Body Fat Mass and Induction of CYP1A2 on the Pharmacokinetics of TCDD

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly lipophilic chemical that distributes into adipose tissue, especially at low doses. However, at high doses TCDD sequesters in liver because it induces cytochrome P450 1A2 (CYP1A2) that binds TCDD. A physiologically based pharmacokinetic (PBPK) mo...

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Detalles Bibliográficos
Autores principales: Emond, Claude, Birnbaum, Linda S., DeVito, Michael J.
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570044/
https://www.ncbi.nlm.nih.gov/pubmed/16966094
http://dx.doi.org/10.1289/ehp.8805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570044/
https://www.ncbi.nlm.nih.gov/pubmed/16966094
http://dx.doi.org/10.1289/ehp.8805

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