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Somatic deletion of the NF1 gene in a neurofibromatosis type 1-associated malignant melanoma demonstrated by digital PCR

BACKGROUND: Neurofibromatosis type 1 (NF1) is the most common hereditary neurocutaneous disorder and it is associated with an elevated risk for malignant tumors of tissues derived from neural crest cells. The NF1 gene is considered a tumor suppressor gene and inactivation of both copies can be found...

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Detalles Bibliográficos
Autores principales: Rübben, Albert, Bausch, Birke, Nikkels, Arjen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570477/
https://www.ncbi.nlm.nih.gov/pubmed/16961930
http://dx.doi.org/10.1186/1476-4598-5-36