Fibrillar beta-amyloid peptide Aβ(1–40 )activates microglial proliferation via stimulating TNF-α release and H(2)O(2 )derived from NADPH oxidase: a cell culture study

BACKGROUND: Alzheimer's disease is characterized by the accumulation of neuritic plaques, containing activated microglia and β-amyloid peptides (Aβ). Fibrillar Aβ can activate microglia, resulting in production of toxic and inflammatory mediators like hydrogen peroxide, nitric oxide, and cytoki...

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Detalles Bibliográficos
Autores principales: Jekabsone, Aiste, Mander, Palwinder K, Tickler, Anna, Sharpe, Martyn, Brown, Guy C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574293/
https://www.ncbi.nlm.nih.gov/pubmed/16959029
http://dx.doi.org/10.1186/1742-2094-3-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574293/
https://www.ncbi.nlm.nih.gov/pubmed/16959029
http://dx.doi.org/10.1186/1742-2094-3-24

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