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Fibrillar beta-amyloid peptide Aβ(1–40 )activates microglial proliferation via stimulating TNF-α release and H(2)O(2 )derived from NADPH oxidase: a cell culture study
BACKGROUND: Alzheimer's disease is characterized by the accumulation of neuritic plaques, containing activated microglia and β-amyloid peptides (Aβ). Fibrillar Aβ can activate microglia, resulting in production of toxic and inflammatory mediators like hydrogen peroxide, nitric oxide, and cytoki...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574293/ https://www.ncbi.nlm.nih.gov/pubmed/16959029 http://dx.doi.org/10.1186/1742-2094-3-24 |