Similar folds with different stabilization mechanisms: the cases of prion and doppel proteins

BACKGROUND: Protein misfolding is the main cause of a group of fatal neurodegenerative diseases in humans and animals. In particular, in Prion-related diseases the normal cellular form of the Prion Protein PrP (PrP(C)) is converted into the infectious PrP(Sc )through a conformational process during...

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Detalles Bibliográficos
Autores principales: Colacino, Stefano, Tiana, Guido, Colombo, Giorgio
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574322/
https://www.ncbi.nlm.nih.gov/pubmed/16857062
http://dx.doi.org/10.1186/1472-6807-6-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574322/
https://www.ncbi.nlm.nih.gov/pubmed/16857062
http://dx.doi.org/10.1186/1472-6807-6-17

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