Targeted Molecular Dynamics Study of C-Loop Closure and Channel Gating in Nicotinic Receptors

The initial coupling between ligand binding and channel gating in the human α7 nicotinic acetylcholine receptor (nAChR) has been investigated with targeted molecular dynamics (TMD) simulation. During the simulation, eight residues at the tip of the C-loop in two alternating subunits were forced to m...

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Detalles Bibliográficos
Autores principales: Cheng, Xiaolin, Wang, Hailong, Grant, Barry, Sine, Steven M, McCammon, J. Andrew
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1584325/
https://www.ncbi.nlm.nih.gov/pubmed/17009865
http://dx.doi.org/10.1371/journal.pcbi.0020134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1584325/
https://www.ncbi.nlm.nih.gov/pubmed/17009865
http://dx.doi.org/10.1371/journal.pcbi.0020134

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