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A novel electron paramagnetic resonance-based assay for prostaglandin H synthase-1 activity

BACKGROUND: Prostaglandin H(2 )synthase (PGHS) is the enzyme that catalyses the two-stage conversion of arachidonic acid to prostaglandin H(2 )(PGH(2)) prior to formation of prostanoids that are important in inflammation. PGHS isozymes (-1 and -2) are the target for nonsteroidal anti-inflammatory dr...

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Detalles Bibliográficos
Autores principales: Turnbull, Catriona M, McClure, Danny, Rossi, Adriano G, Megson, Ian L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592475/
https://www.ncbi.nlm.nih.gov/pubmed/17007643
http://dx.doi.org/10.1186/1476-9255-3-12