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Construction of doxycyline-dependent mini-HIV-1 variants for the development of a virotherapy against leukemias

T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk type of blood-cell cancer. We describe the improvement of a candidate therapeutic virus for virotherapy of leukemic cells. Virotherapy is based on the exclusive replication of a virus in leukemic cells, leading to the selective removal of th...

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Detalles Bibliográficos
Autores principales: Jeeninga, Rienk E, Jan, Barbara, van den Berg, Henk, Berkhout, Ben
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592508/
https://www.ncbi.nlm.nih.gov/pubmed/17005036
http://dx.doi.org/10.1186/1742-4690-3-64