Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa

BACKGROUND: In vitro and in vivo resistance of Plasmodium falciparum to atovaquone or atovaquone-proguanil hydrochloride combination has been associated to two point mutations in the parasite cytochrome b (cytb) gene (Tyr268Ser and Tyr268Asn). However, little is known about the prevalence of codon-2...

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Detalles Bibliográficos
Autores principales: Happi, Christian T, Gbotosho, Grace O, Folarin, Onikepe A, Milner, Danny, Sarr, Ousmane, Sowunmi, Akintunde, Kyle, Dennis E, Milhous, Wilbur K, Wirth, Dyann F, Oduola, Ayoade MJ
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1594577/
https://www.ncbi.nlm.nih.gov/pubmed/17020611
http://dx.doi.org/10.1186/1475-2875-5-82

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1594577/
https://www.ncbi.nlm.nih.gov/pubmed/17020611
http://dx.doi.org/10.1186/1475-2875-5-82

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