Cargando…

Inhibition of Interferon-γ Signaling in Oligodendroglia Delays Coronavirus Clearance without Altering Demyelination

Infection of the central nervous system (CNS) by the neurotropic JHM strain of mouse hepatitis virus (JHMV) induces an acute encephalomyelitis associated with demyelination. To examine the anti-viral and/or regulatory role of interferon-γ (IFN-γ) signaling in the cell that synthesizes and maintains...

Descripción completa

Detalles Bibliográficos
Autores principales:	González, John M., Bergmann, Cornelia C., Ramakrishna, Chandran, Hinton, David R., Atkinson, Roscoe, Hoskin, Jason, Macklin, Wendy B., Stohlman, Stephen A.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Investigative Pathology 2006
Materias:	Original Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1606538/ https://www.ncbi.nlm.nih.gov/pubmed/16507895 http://dx.doi.org/10.2353/ajpath.2006.050496

Ejemplares similares

Oligodendroglia are limited in type I interferon induction and responsiveness in vivo
por: Kapil, Parul, et al.
Publicado: (2012)

RNase L Mediated Protection from Virus Induced Demyelination
por: Ireland, Derek D. C., et al.
Publicado: (2009)

Mouse hepatitis virus pathogenesis in the central nervous system is independent of IL-15 and natural killer cells
por: Zuo, Jun, et al.
Publicado: (2006)

Coronavirus Immunity: From T Cells to B Cells
por: Bergmann, Cornelia C., et al.
Publicado: (2006)

The Role of Humoral Immunity in Mouse Hepatitis Virus Induced Demyelination
por: Ramakrishna, C., et al.
Publicado: (2005)

Viral Induced Demyelination
por: Stohlman, Stephen A., et al.
Publicado: (2006)

IFN-γ Signaling to Astrocytes Protects from Autoimmune Mediated Neurological Disability
por: Hindinger, Claudia, et al.
Publicado: (2012)

Glia Expression of MHC During CNS Infection by Neurotropic Coronavirus
por: Malone, Karen E., et al.
Publicado: (2006)

The Role of T Cells in Corona-Virus-Induced Demyelination
por: Bergmann, Cornelia C, et al.
Publicado: (2005)

Expression of Interferon-γ by a Coronavirus Defective-Interfering RNA Vector and Its Effect on Viral Replication, Spread, and Pathogenicity
por: Zhang, Xuming, et al.
Publicado: (1997)

Interleukin‐10 is a critical regulator of white matter lesion containment following viral induced demyelination
por: Puntambekar, Shweta S., et al.
Publicado: (2015)

Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination
por: Rodriguez, Enrique Garea, et al.
Publicado: (2014)

Primary demyelination in transgenic mice expressing interferon-γ
por: Horwitz, Marc S., et al.
Publicado: (1997)

Self-reactive CD4(+) T cells activated during viral-induced demyelination do not prevent clinical recovery
por: Savarin, Carine, et al.
Publicado: (2015)

The oligodendroglia cytoskeleton in health and disease
por: Richter-Landsberg, Christiane
Publicado: (2015)

Role of IFN-γ responsiveness in CD8 T cell-mediated viral clearance and demyelination in coronavirus-infected mice
por: Templeton, Steven P., et al.
Publicado: (2008)

IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils
por: Savarin, Carine, et al.
Publicado: (2012)

Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ-Dependent in a Coronavirus Model of Multiple Sclerosis
por: Dandekar, Ajai A., et al.
Publicado: (2004)

Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis
por: Savarin, Carine, et al.
Publicado: (2015)

Oligodendroglia metabolically support axons and contribute to neurodegeneration
por: Lee, Youngjin, et al.
Publicado: (2012)

Altered oligodendroglia and astroglia in chronic traumatic encephalopathy
por: Chancellor, K. Blake, et al.
Publicado: (2021)

Oligodendroglia heterogeneity in the human central nervous system
por: Seeker, Luise A., et al.
Publicado: (2021)

Viral-induced suppression of self-reactive T cells: Lessons from neurotropic coronavirus-induced demyelination
por: Savarin, Carine, et al.
Publicado: (2017)

Coronavirus infection of the central nervous system: host–virus stand-off
por: Bergmann, Cornelia C., et al.
Publicado: (2006)

Adenosine Actions on Oligodendroglia and Myelination in Autism Spectrum Disorder
por: Shen, Hai-Ying, et al.
Publicado: (2018)

Oligodendroglia are emerging players in several forms of learning and memory
por: Munyeshyaka, Maxime, et al.
Publicado: (2022)

The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration
por: Fodder, Katherine, et al.
Publicado: (2023)

MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis
por: Savarin, Carine, et al.
Publicado: (2013)

PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis
por: Kapil, Parul, et al.
Publicado: (2014)

Differential Regulation of Self-reactive CD4(+) T Cells in Cervical Lymph Nodes and Central Nervous System during Viral Encephalomyelitis
por: Savarin, Carine, et al.
Publicado: (2016)

Distinct Gene Profiles of Bone Marrow-Derived Macrophages and Microglia During Neurotropic Coronavirus-Induced Demyelination
por: Savarin, Carine, et al.
Publicado: (2018)

Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system
por: de Aquino, Maria Teresa P., et al.
Publicado: (2013)

Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis
por: Phares, Timothy W, et al.
Publicado: (2012)

PD-1 Regulates Neural Damage in Oligodendroglia-Induced Inflammation
por: Kroner, Antje, et al.
Publicado: (2009)

Oligodendroglia Are Particularly Vulnerable to Oxidative Damage After Neurotrauma In Vivo
por: Giacci, Marcus, et al.
Publicado: (2018)

Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?
por: Ettle, Benjamin, et al.
Publicado: (2015)

Oligodendroglia-to-neuron material transfer lights up the mouse CNS
por: Pluchino, Stefano, et al.
Publicado: (2023)

Experimental demyelination induced by coronavirus JHM (MHV-4): molecular identification of a viral determinant of paralytic disease()
por: Fleming, J.O., et al.
Publicado: (1987)

Correction: PD-1 Regulates Neural Damage in Oligodendroglia-Induced Inflammation
por: Kroner, Antje, et al.
Publicado: (2011)

In vivo Optogenetic Approach to Study Neuron-Oligodendroglia Interactions in Mouse Pups
por: Ortolani, Domiziana, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_kl4keias6ejmkmofhpaqg65lfi