Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells

BACKGROUND: The Wnt signaling pathway is activated by mutations in the APC and β-catenin genes in many types of human cancer. β-catenin is stabilized by these mutations and activates transcription in part by acting as a bridge between Tcf/LEF proteins and the HD2 domain of the BCL9 coactivator. We h...

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Detalles Bibliográficos
Autores principales: Fuerer, Christophe, Homicsko, Krisztian, Lukashev, Alexander N, Pittet, Anne-Laure, Iggo, Richard D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1609183/
https://www.ncbi.nlm.nih.gov/pubmed/17020613
http://dx.doi.org/10.1186/1471-2407-6-236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1609183/
https://www.ncbi.nlm.nih.gov/pubmed/17020613
http://dx.doi.org/10.1186/1471-2407-6-236

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