RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts

BACKGROUND: Incorrect segregation of whole chromosomes or parts of chromosome leads to aneuploidy commonly observed in cancer. The correct centrosome duplication, assuring assembly of a bipolar mitotic spindle, is essential for chromosome segregation fidelity and preventing aneuploidy. Alteration of...

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Detalles Bibliográficos
Autores principales: Iovino, Flora, Lentini, Laura, Amato, Angela, Di Leonardo, Aldo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1613254/
https://www.ncbi.nlm.nih.gov/pubmed/16987420
http://dx.doi.org/10.1186/1476-4598-5-38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1613254/
https://www.ncbi.nlm.nih.gov/pubmed/16987420
http://dx.doi.org/10.1186/1476-4598-5-38

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