A Role for PCNA Ubiquitination in Immunoglobulin Hypermutation

Proliferating cell nuclear antigen (PCNA) is a DNA polymerase cofactor and regulator of replication-linked functions. Upon DNA damage, yeast and vertebrate PCNA is modified at the conserved lysine K164 by ubiquitin, which mediates error-prone replication across lesions via translesion polymerases. W...

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Detalles Bibliográficos
Autores principales: Arakawa, Hiroshi, Moldovan, George-Lucian, Saribasak, Huseyin, Saribasak, Nesibe Nur, Jentsch, Stefan, Buerstedde, Jean-Marie
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618868/
https://www.ncbi.nlm.nih.gov/pubmed/17105346
http://dx.doi.org/10.1371/journal.pbio.0040366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618868/
https://www.ncbi.nlm.nih.gov/pubmed/17105346
http://dx.doi.org/10.1371/journal.pbio.0040366

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