Targeting of mutant hogg1 in mammalian mitochondria and nucleus: effect on cellular survival upon oxidative stress

BACKGROUND: Oxidative damage to mitochondrial DNA has been implicated as a causative factor in a wide variety of degenerative diseases, aging and cancer. The modified guanine, 7,8-dihydro-8-oxoguanine (also known as 8-hydroxyguanine) is one of the major oxidized bases generated in DNA by reactive ox...

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Detalles Bibliográficos
Autores principales: Chatterjee, Aditi, Mambo, Elizabeth, Zhang, Yonggang, DeWeese, Theodore, Sidransky, David
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1633743/
https://www.ncbi.nlm.nih.gov/pubmed/17018150
http://dx.doi.org/10.1186/1471-2407-6-235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1633743/
https://www.ncbi.nlm.nih.gov/pubmed/17018150
http://dx.doi.org/10.1186/1471-2407-6-235

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