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Homology modeling using parametric alignment ensemble generation with consensus and energy-based model selection

The accuracy of a homology model based on the structure of a distant relative or other topologically equivalent protein is primarily limited by the quality of the alignment. Here we describe a systematic approach for sequence-to-structure alignment, called ‘K*Sync’, in which alignments are generated...

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Detalles Bibliográficos
Autores principales: Chivian, Dylan, Baker, David
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635247/
https://www.ncbi.nlm.nih.gov/pubmed/16971460
http://dx.doi.org/10.1093/nar/gkl480