Cargando…

Mimicking damaged DNA with a small molecule inhibitor of human UNG2

Human nuclear uracil DNA glycosylase (UNG2) is a cellular DNA repair enzyme that is essential for a number of diverse biological phenomena ranging from antibody diversification to B-cell lymphomas and type-1 human immunodeficiency virus infectivity. During each of these processes, UNG2 recognizes ur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krosky, Daniel J., Bianchet, Mario A., Seiple, Lauren, Chung, Suhman, Amzel, L. Mario, Stivers, James T.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635321/ https://www.ncbi.nlm.nih.gov/pubmed/17062624 http://dx.doi.org/10.1093/nar/gkl747

Ejemplares similares

Impact of linker strain and flexibility in the design of a fragment-based inhibitor
por: Chung, Suhman, et al.
Publicado: (2009)

Structural and biophysical analysis of interactions between cod and human uracil-DNA N-glycosylase (UNG) and UNG inhibitor (Ugi)
por: Assefa, Netsanet Gizaw, et al.
Publicado: (2014)

Specificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase α4 helix
por: Hobaika, Zeina, et al.
Publicado: (2009)

How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape
por: Bardaro, Michael F., et al.
Publicado: (2009)

Sequence-dependent gating of an ion channel by DNA hairpin molecules
por: DeGuzman, Veronica S., et al.
Publicado: (2006)

Riboswitch structure: an internal residue mimicking the purine ligand
por: Delfosse, Vanessa, et al.
Publicado: (2010)

Interaction of cationic surfactants with DNA: a single-molecule study
por: Husale, Sudhir, et al.
Publicado: (2008)

A small molecule directly inhibits the p53 transactivation domain from binding to replication protein A
por: Glanzer, Jason G., et al.
Publicado: (2013)

Organelle-mimicking liposome dissociates G-quadruplexes and facilitates transcription
por: Pramanik, Smritimoy, et al.
Publicado: (2014)

Two convergent pathways of DNA knotting in replicating DNA molecules as revealed by θ-curve analysis
por: O’Donnol, Danielle, et al.
Publicado: (2018)

N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA–dsDNA junctions
por: Weiser, Brian P, et al.
Publicado: (2018)

Effects of physiological self-crowding of DNA on shape and biological properties of DNA molecules with various levels of supercoiling
por: Benedetti, Fabrizio, et al.
Publicado: (2015)

Processing oxidatively damaged bases at DNA strand breaks by APE1
por: Whitaker, Amy M, et al.
Publicado: (2022)

Influence of cationic molecules on the hairpin to duplex equilibria of self-complementary DNA and RNA oligonucleotides
por: Nakano, Shu-ichi, et al.
Publicado: (2007)

How does temperature impact the conformation of single DNA molecules below melting temperature?
por: Brunet, Annaël, et al.
Publicado: (2018)

G-quadruplexes with (4n - 1) guanines in the G-tetrad core: formation of a G-triad·water complex and implication for small-molecule binding
por: Heddi, Brahim, et al.
Publicado: (2016)

Effective stiffening of DNA due to nematic ordering causes DNA molecules packed in phage capsids to preferentially form torus knots
por: Reith, Daniel, et al.
Publicado: (2012)

How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion
por: Chao, Luke H, et al.
Publicado: (2018)

Single-molecule FRET analysis of DNA binding and bending by yeast HMGB protein Nhp6A
por: Coats, Julie E., et al.
Publicado: (2013)

Structure and DNA damage-dependent derepression mechanism for the XRE family member DG-DdrO
por: Lu, Huizhi, et al.
Publicado: (2019)

Crystal structures of DNA:DNA and DNA:RNA duplexes containing 5-(N-aminohexyl)carbamoyl-modified uracils reveal the basis for properties as antigene and antisense molecules
por: Juan, Ella Czarina Magat, et al.
Publicado: (2007)

Tethering-facilitated DNA ‘opening’ and complementary roles of β-hairpin motifs in the Rad4/XPC DNA damage sensor protein
por: Paul, Debamita, et al.
Publicado: (2020)

Structural and functional characterization of DdrC, a novel DNA damage-induced nucleoid associated protein involved in DNA compaction
por: Banneville, Anne-Sophie, et al.
Publicado: (2022)

Small molecule-mediated refolding and activation of myosin motor function
por: Radke, Michael B, et al.
Publicado: (2014)

High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A π-stacking interactions for small-molecule recognition
por: Ou, Arnold, et al.
Publicado: (2020)

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1
por: Rappas, Mathieu, et al.
Publicado: (2011)

Single-molecule DNA unzipping reveals asymmetric modulation of a transcription factor by its binding site sequence and context
por: Rudnizky, Sergei, et al.
Publicado: (2018)

CpG and methylation-dependent DNA binding and dynamics of the methylcytosine binding domain 2 protein at the single-molecule level
por: Pan, Hai, et al.
Publicado: (2017)

Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme
por: Benjdia, Alhosna, et al.
Publicado: (2012)

UV damage endonuclease employs a novel dual-dinucleotide flipping mechanism to recognize different DNA lesions
por: Meulenbroek, Elisabeth M., et al.
Publicado: (2013)

Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor
por: Wang, Hao-Ching, et al.
Publicado: (2014)

Internally labeled Cy3/Cy5 DNA constructs show greatly enhanced photo-stability in single-molecule FRET experiments
por: Lee, Wonbae, et al.
Publicado: (2014)

Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism
por: Satange, Roshan, et al.
Publicado: (2022)

Structural basis for sequence-dependent recognition of colicin E5 tRNase by mimicking the mRNA–tRNA interaction
por: Yajima, Shunsuke, et al.
Publicado: (2006)

Crystal structure of the UvrB dimer: insights into the nature and functioning of the UvrAB damage engagement and UvrB–DNA complexes
por: Webster, Matthew P. J., et al.
Publicado: (2012)

NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes
por: Winnerdy, Fernaldo Richtia, et al.
Publicado: (2019)

Exclusion of small terminase mediated DNA threading models for genome packaging in bacteriophage T4
por: Gao, Song, et al.
Publicado: (2016)

Uracil–DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms
por: Pettersen, Henrik Sahlin, et al.
Publicado: (2007)

Solution structures of 2 : 1 and 1 : 1 DNA polymerase–DNA complexes probed by ultracentrifugation and small-angle X-ray scattering
por: Tang, Kuo-Hsiang, et al.
Publicado: (2008)

Linking uracil base excision repair and 5-fluorouracil toxicity in yeast
por: Seiple, Lauren, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_ovprrll55348rv20ci9lecdmfe