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p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans

The PMK-1 p38 mitogen-activated protein kinase pathway and the DAF-2–DAF-16 insulin signaling pathway control Caenorhabditis elegans intestinal innate immunity. pmk-1 loss-of-function mutants have enhanced sensitivity to pathogens, while daf-2 loss-of-function mutants have enhanced resistance to pat...

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Detalles Bibliográficos
Autores principales: Troemel, Emily R, Chu, Stephanie W, Reinke, Valerie, Lee, Siu Sylvia, Ausubel, Frederick M, Kim, Dennis H
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635533/
https://www.ncbi.nlm.nih.gov/pubmed/17096597
http://dx.doi.org/10.1371/journal.pgen.0020183