Cargando…

SMC3 knockdown triggers genomic instability and p53-dependent apoptosis in human and zebrafish cells

BACKGROUND: The structural maintenance of chromosome 3 (SMC3) protein is a constituent of a number of nuclear multimeric protein complexes that are involved in DNA recombination and repair in addition to chromosomal segregation. Overexpression of SMC3 activates a tumorigenic cascade through which ma...

Descripción completa

Detalles Bibliográficos
Autor principal:	Ghiselli, Giancarlo
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636066/ https://www.ncbi.nlm.nih.gov/pubmed/17081288 http://dx.doi.org/10.1186/1476-4598-5-52

Ejemplares similares

Global gene expression profiling of cells overexpressing SMC3
por: Ghiselli, Giancarlo, et al.
Publicado: (2005)

p53-mediated apoptosis and genomic instability syndromes
por: Spillare, EA, et al.
Publicado: (2000)

Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3
por: Patel, Chirag A, et al.
Publicado: (2005)

Genomic Instability Associated with p53 Knockdown in the Generation of Huntington’s Disease Human Induced Pluripotent Stem Cells
por: Tidball, Andrew M., et al.
Publicado: (2016)

Functions of SMC2 in the Development of Zebrafish Liver
por: Li, Xixi, et al.
Publicado: (2021)

Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells
por: Liu, Tuoen, et al.
Publicado: (2017)

Knockdown of MBP-1 in Human Foreskin Fibroblasts Induces p53-p21 Dependent Senescence
por: Ghosh, Asish K., et al.
Publicado: (2008)

Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells
por: Pruschy, M, et al.
Publicado: (1999)

p53 Activation by Knockdown Technologies
por: Robu, Mara E, et al.
Publicado: (2007)

Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability
por: Wen, Weihong, et al.
Publicado: (2013)

POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim()()()()()
por: Wang, Chun-Hua, et al.
Publicado: (2018)

Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors
por: Lei, Lei, et al.
Publicado: (2017)

Knockdown of CDK2AP1 in Primary Human Fibroblasts Induces p53 Dependent Senescence
por: Alsayegh, Khaled N., et al.
Publicado: (2015)

Liver-Specific Expressions of HBx and src in the p53 Mutant Trigger Hepatocarcinogenesis in Zebrafish
por: Lu, Jeng-Wei, et al.
Publicado: (2013)

SMC1A knockdown induces growth suppression of human lung adenocarcinoma cells through G1/S cell cycle phase arrest and apoptosis pathways in vitro
por: ZHANG, YI-FAN, et al.
Publicado: (2013)

Thiamine antagonists trigger p53-dependent apoptosis in differentiated SH-SY5Y cells
por: Chornyy, Sergiy, et al.
Publicado: (2017)

p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol
por: Carlsson, Max J., et al.
Publicado: (2022)

Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging
por: Li, Tongyuan, et al.
Publicado: (2016)

The SMC1-SMC3 cohesin heterodimer structures DNA through supercoiling-dependent loop formation
por: Sun, Mingxuan, et al.
Publicado: (2013)

The ARTS of p53-dependent mitochondrial apoptosis
por: Hao, Qian, et al.
Publicado: (2022)

D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish
por: Ghiselli, Giancarlo, et al.
Publicado: (2005)

PEG-b-PCL polymeric nano-micelle inhibits vascular angiogenesis by activating p53-dependent apoptosis in zebrafish
por: Zhou, Tian, et al.
Publicado: (2016)

Loss of rps9 in Zebrafish Leads to p53-Dependent Anemia
por: Chen, Cheng, et al.
Publicado: (2019)

Knockdown of TXNDC9 induces apoptosis and autophagy in glioma and mediates cell differentiation by p53 activation
por: Zheng, Tingting, et al.
Publicado: (2020)

Mdmx promotes genomic instability independent of p53 and Mdm2
por: Carrillo, Alexia M., et al.
Publicado: (2014)

p53 coordinates base excision repair to prevent genomic instability
por: Poletto, Mattia, et al.
Publicado: (2016)

Lack of Major Genome Instability in Tumors of p53 Null Rats
por: Hermsen, Roel, et al.
Publicado: (2015)

Apc and p53 interaction in DNA damage and genomic instability in hepatocytes
por: Méniel, Valérie, et al.
Publicado: (2014)

Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53
por: Ohnishi, Takeo, et al.
Publicado: (2002)

Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic
por: Eeftens, Jorine M., et al.
Publicado: (2016)

Overexpression of DRAM enhances p53-dependent apoptosis
por: Takahashi, Masahiro, et al.
Publicado: (2013)

LKB1 inactivation leads to centromere defects and genome instability via p53-dependent upregulation of survivin
por: Jin, Li-Yan, et al.
Publicado: (2020)

New results on the spin dependent structure function $g_{1}^{p}$ from SMC
por: Magnon, A
Publicado: (1997)

Cadmium Induces p53-Dependent Apoptosis in Human Prostate Epithelial Cells
por: Aimola, Pierpaolo, et al.
Publicado: (2012)

Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis
por: Kovács, Dávid, et al.
Publicado: (2016)

Knockdown of Dinoflagellate Condensin CcSMC4 Subunit Leads to S-Phase Impediment and Decompaction of Liquid Crystalline Chromosomes
por: Yan, Ting Hin Kosmo, et al.
Publicado: (2020)

Meiotic DNA joint molecule resolution depends on Nse5–Nse6 of the Smc5–Smc6 holocomplex
por: Wehrkamp-Richter, Sophie, et al.
Publicado: (2012)

Dendrosomal nanocurcumin and p53 overexpression synergistically trigger apoptosis in glioblastoma cells
por: Keshavarz, Reihaneh, et al.
Publicado: (2016)

In‐frame deletion of SMC5 related with the phenotype of primordial dwarfism, chromosomal instability and insulin resistance
por: Zhu, Wenjiao, et al.
Publicado: (2023)

Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis
por: So, E Y, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_60ce9g2lplghsclmnok5p1i0a8