Cargando…

Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice

RNA interference (RNAi) has great potential as a tool for studying gene function in mammals. However, the specificity and magnitude of the in vivo response to RNAi remains to be fully characterized. A molecular and phenotypic comparison of a genetic knockout mouse and the corresponding knockdown ver...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Souza, Angus T., Dai, Xudong, Spencer, Andrew G., Reppen, Tom, Menzie, Ann, Roesch, Paula L., He, Yudong, Caguyong, Michelle J., Bloomer, Sherri, Herweijer, Hans, Wolff, Jon A., Hagstrom, James E., Lewis, David L., Linsley, Peter S., Ulrich, Roger G.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636368/ https://www.ncbi.nlm.nih.gov/pubmed/16945951 http://dx.doi.org/10.1093/nar/gkl609

Ejemplares similares

PPARα siRNA–Treated Expression Profiles Uncover the Causal Sufficiency Network for Compound-Induced Liver Hypertrophy
por: Dai, Xudong, et al.
Publicado: (2007)

Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect
por: Clark, Paul R., et al.
Publicado: (2008)

Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 ‘Slicer’ independent and can be mediated by Ago1
por: Vickers, Timothy A., et al.
Publicado: (2009)

Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates
por: Cuellar, Trinna L., et al.
Publicado: (2015)

Inhibition of MDR1 expression with altritol-modified siRNAs
por: Fisher, Michael, et al.
Publicado: (2007)

Competition for RISC binding predicts in vitro potency of siRNA
por: Koller, Erich, et al.
Publicado: (2006)

Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells
por: Vickers, Timothy A., et al.
Publicado: (2007)

Live cell imaging of duplex siRNA intracellular trafficking
por: Hirsch, Markus, et al.
Publicado: (2015)

RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery
por: Lima, Walt F., et al.
Publicado: (2016)

GW body disassembly triggered by siRNAs independently of their silencing activity
por: Serman, A., et al.
Publicado: (2007)

siRNAs compete with miRNAs for methylation by HEN1 in Arabidopsis
por: Yu, Bin, et al.
Publicado: (2010)

A role for human Dicer in pre-RISC loading of siRNAs
por: Sakurai, Kumi, et al.
Publicado: (2011)

Sequencing of RDR6-dependent double-stranded RNAs reveals novel features of plant siRNA biogenesis
por: Rajeswaran, Rajendran, et al.
Publicado: (2012)

RNA major groove modifications improve siRNA stability and biological activity
por: Terrazas, Montserrat, et al.
Publicado: (2009)

Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs
por: Vaish, Narendra, et al.
Publicado: (2011)

mRNA knockdown by single strand RNA is improved by chemical modifications
por: Haringsma, Henry J., et al.
Publicado: (2012)

Effective knockdown of Drosophila long non-coding RNAs by CRISPR interference
por: Ghosh, Sanjay, et al.
Publicado: (2016)

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect
por: Ui-Tei, Kumiko, et al.
Publicado: (2008)

Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron
por: Liu, Ying Poi, et al.
Publicado: (2008)

Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification
por: Puthenveetil, Sujiet, et al.
Publicado: (2006)

Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth
por: Crombez, Laurence, et al.
Publicado: (2009)

Strand antagonism in RNAi: an explanation of differences in potency between intracellularly expressed siRNA and shRNA
por: Jin, Xin, et al.
Publicado: (2012)

Delivery of chemo-sensitizing siRNAs to HER2(+)-breast cancer cells using RNA aptamers
por: Thiel, Kristina W., et al.
Publicado: (2012)

siRNAs targeted to certain polyadenylation sites promote specific, RISC-independent degradation of messenger RNAs
por: Vickers, Timothy A., et al.
Publicado: (2012)

Development of modified siRNA molecules incorporating 5-fluoro-2′-deoxyuridine residues to enhance cytotoxicity
por: Wu, Shao-yu, et al.
Publicado: (2013)

siPools: highly complex but accurately defined siRNA pools eliminate off-target effects
por: Hannus, Michael, et al.
Publicado: (2014)

Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA
por: Liu, Xiaoxia, et al.
Publicado: (2014)

Primary and secondary siRNA synthesis triggered by RNAs from food bacteria in the ciliate Paramecium tetraurelia
por: Carradec, Quentin, et al.
Publicado: (2015)

Genome-wide analysis of single non-templated nucleotides in plant endogenous siRNAs and miRNAs
por: Wang, Feng, et al.
Publicado: (2016)

siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2
por: Elkayam, Elad, et al.
Publicado: (2017)

Dual functional BAFF receptor aptamers inhibit ligand-induced proliferation and deliver siRNAs to NHL cells
por: Zhou, Jiehua, et al.
Publicado: (2013)

Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants
por: Snead, Nicholas M., et al.
Publicado: (2013)

Functional VEGFA knockdown with artificial 3′-tailed mirtrons defined by 5′ splice site and branch point
por: Kock, Kian Hong, et al.
Publicado: (2015)

The miRNA pathway limits AGO1 availability during siRNA-mediated PTGS defense against exogenous RNA
por: Martínez de Alba, Angel Emilio, et al.
Publicado: (2011)

Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development
por: Ohnishi, Yusuke, et al.
Publicado: (2010)

Deep sequencing of small RNAs identifies canonical and non-canonical miRNA and endogenous siRNAs in mammalian somatic tissues
por: Castellano, Leandro, et al.
Publicado: (2013)

Transcribed pseudogene ψPPM1K generates endogenous siRNA to suppress oncogenic cell growth in hepatocellular carcinoma
por: Chan, Wen-Ling, et al.
Publicado: (2013)

Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells
por: Takahashi, Tomoko, et al.
Publicado: (2014)

Thermodynamic stability and Watson–Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect
por: Ui-Tei, Kumiko, et al.
Publicado: (2008)

Strand selective generation of endo-siRNAs from the Na/phosphate transporter gene Slc34a1 in murine tissues
por: Carlile, Mark, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_qngdnc6lm8pifro5lspgal024s