Cargando…

Targeting chromosomal sites with locked nucleic acid-modified triplex-forming oligonucleotides: study of efficiency dependence on DNA nuclear environment

Triplex-forming oligonucleotides (TFOs) are synthetic DNA code-reading molecules that have been demonstrated to function to some extent in chromatin within cell nuclei. Here we have investigated the impact of DNA nuclear environment on the efficiency of TFO binding. For this study we have used locke...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brunet, Erika, Corgnali, Maddalena, Cannata, Fabio, Perrouault, Loïc, Giovannangeli, Carine
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636373/ https://www.ncbi.nlm.nih.gov/pubmed/16951289 http://dx.doi.org/10.1093/nar/gkl630

Ejemplares similares

Intercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities
por: Brunet, Erika, et al.
Publicado: (2005)

Optimal design of parallel triplex forming oligonucleotides containing Twisted Intercalating Nucleic Acids—TINA
por: Schneider, Uffe V., et al.
Publicado: (2010)

Sequence-specific DNA cleavage mediated by bipyridine polyamide conjugates
por: Simon, Philippe, et al.
Publicado: (2008)

Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides
por: Duca, Maria, et al.
Publicado: (2006)

Recent Advancements in Development and Therapeutic Applications of Genome-Targeting Triplex-Forming Oligonucleotides and Peptide Nucleic Acids
por: Mikame, Yu, et al.
Publicado: (2023)

Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA
por: Moreno, Pedro M. D., et al.
Publicado: (2013)

Homology-directed Fanconi anemia pathway crosslink repair is dependent on DNA replication
por: Nakanishi, Koji, et al.
Publicado: (2011)

Secondary binding sites for heavily modified triplex forming oligonucleotides
por: Cardew, Antonia S., et al.
Publicado: (2012)

Structural Determinants of Photoreactivity of Triplex Forming Oligonucleotides Conjugated to Psoralens
por: Krishnan, Rajagopal, et al.
Publicado: (2010)

Recognition of RNA duplexes by chemically modified triplex-forming oligonucleotides
por: Zhou, Yuan, et al.
Publicado: (2013)

Triplex-forming oligonucleotides: a third strand for DNA nanotechnology
por: Chandrasekaran, Arun Richard, et al.
Publicado: (2018)

Triplex-forming oligonucleotides as an anti-gene technique for cancer therapy
por: Li, Chun, et al.
Publicado: (2022)

Recent Development in Biomedical Applications of Oligonucleotides with Triplex-Forming Ability
por: Bekkouche, Incherah, et al.
Publicado: (2023)

Nuclear and Cytoplasmatic Quantification of Unconjugated, Label-Free Locked Nucleic Acid Oligonucleotides
por: Pendergraff, Hannah, et al.
Publicado: (2020)

Four base recognition by triplex-forming oligonucleotides at physiological pH
por: Rusling, David A., et al.
Publicado: (2005)

Targeting duplex DNA with chimeric α,β-triplex-forming oligonucleotides
por: Kolganova, N. A., et al.
Publicado: (2012)

Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies
por: Hartono, Yossa Dwi, et al.
Publicado: (2017)

Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications
por: McGorman, Bríonna, et al.
Publicado: (2022)

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates
por: Straarup, Ellen Marie, et al.
Publicado: (2010)

A capture approach for supercoiled plasmid DNA using a triplex-forming oligonucleotide
por: Ruigrok, Vincent J. B., et al.
Publicado: (2013)

Cellular antisense activity of peptide nucleic acid (PNAs) targeted to HIV-1 polypurine tract (PPT) containing RNA
por: Boutimah-Hamoudi, Fatima, et al.
Publicado: (2007)

Impact of Chirality and Position of Lysine Conjugation in Triplex-Forming Peptide Nucleic Acids
por: Ryan, Christopher A., et al.
Publicado: (2020)

Application of Locked Nucleic Acid Oligonucleotides for siRNA Preclinical Bioanalytics
por: Thayer, Mai B., et al.
Publicado: (2019)

Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions
por: Goñi, Josep Ramon, et al.
Publicado: (2006)

Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides
por: Bailey, Jeffrey K., et al.
Publicado: (2017)

Design and evaluation of locked nucleic acid-based splice-switching oligonucleotides in vitro
por: Shimo, Takenori, et al.
Publicado: (2014)

Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides
por: Burdick, Andrew D., et al.
Publicado: (2014)

Cytotoxic effects and specific gene expression alterations induced by I-125-labeled triplex-forming oligonucleotides
por: Dahmen, Volker, et al.
Publicado: (2012)

Incorporation of thio-pseudoisocytosine into triplex-forming peptide nucleic acids for enhanced recognition of RNA duplexes
por: Devi, Gitali, et al.
Publicado: (2014)

Synthesis and investigation of deoxyribonucleic acid/locked nucleic acid chimeric molecular beacons
por: Yang, Chaoyong James, et al.
Publicado: (2007)

Synthetic oligonucleotide antigens modified with locked nucleic acids detect disease specific antibodies
por: Samuelsen, Simone V., et al.
Publicado: (2016)

Synthesis and triplex-forming properties of oligonucleotides capable of recognizing corresponding DNA duplexes containing four base pairs
por: Ohkubo, Akihiro, et al.
Publicado: (2015)

Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides
por: Pyne, Alice L. B., et al.
Publicado: (2021)

A Click Chemistry Approach to Targeted DNA Crosslinking with cis‐Platinum(II)‐Modified Triplex‐Forming Oligonucleotides
por: Hennessy, Joseph, et al.
Publicado: (2021)

Design and In Vitro Evaluation of Splice-Switching Oligonucleotides Bearing Locked Nucleic Acids, Amido-Bridged Nucleic Acids, and Guanidine-Bridged Nucleic Acids
por: Shimo, Takenori, et al.
Publicado: (2021)

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals
por: Swayze, Eric E., et al.
Publicado: (2007)

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents
por: Stein, C. A., et al.
Publicado: (2010)

Targeting miR-9 in gastric cancer cells using locked nucleic acid oligonucleotides
por: Lima, Joana Filipa, et al.
Publicado: (2018)

Targeting murine alveolar macrophages by the intratracheal administration of locked nucleic acid containing antisense oligonucleotides
por: Uemura, Yasunori, et al.
Publicado: (2019)

Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications
por: Thorpe, Cameron, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_b382c891ooa8r2tp8fc8akr3jv