Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites

Indolicidin is a host defense tridecapeptide that inhibits the catalytic activity of HIV-1 integrase in vitro. Here we have elucidated its mechanism of integrase inhibition. Using crosslinking and mass spectrometric footprinting approaches, we found that indolicidin interferes with formation of the...

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Detalles Bibliográficos
Autores principales: Marchand, Christophe, Krajewski, Krzysztof, Lee, Hsiu-Fang, Antony, Smitha, Johnson, Allison A., Amin, Ronak, Roller, Peter, Kvaratskhelia, Mamuka, Pommier, Yves
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636436/
https://www.ncbi.nlm.nih.gov/pubmed/16998183
http://dx.doi.org/10.1093/nar/gkl667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636436/
https://www.ncbi.nlm.nih.gov/pubmed/16998183
http://dx.doi.org/10.1093/nar/gkl667

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