Quantitative analysis of the oxidative DNA lesion, 2,2-diamino-4-(2-deoxy-β-d-erythro-pentofuranosyl)amino]-5(2H)-oxazolone (oxazolone), in vitro and in vivo by isotope dilution-capillary HPLC-ESI-MS/MS

A major DNA oxidation product, 2,2-diamino-4-[(2-deoxy-β-d-erythro-pentofuranosyl)amino]-5(2H)-oxazolone (oxazolone), can be generated either directly by oxidation of dG or as a secondary oxidation product with an intermediate of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG). Site-specific mutagene...

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Detalles Bibliográficos
Autores principales: Matter, Brock, Malejka-Giganti, Danuta, Csallany, A. Saari, Tretyakova, Natalia
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636462/
https://www.ncbi.nlm.nih.gov/pubmed/17020926
http://dx.doi.org/10.1093/nar/gkl596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636462/
https://www.ncbi.nlm.nih.gov/pubmed/17020926
http://dx.doi.org/10.1093/nar/gkl596

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