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Modification of the Tet-On regulatory system prevents the conditional-live HIV-1 variant from losing doxycycline-control
BACKGROUND: We have previously constructed a doxycycline (dox)-dependent HIV-1 variant by incorporating the Tet-On gene regulatory system into the viral genome. Replication of this HIV-rtTA virus is driven by the dox-inducible transactivator protein rtTA, and can be switched on and off at will. We p...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637113/ https://www.ncbi.nlm.nih.gov/pubmed/17094796 http://dx.doi.org/10.1186/1742-4690-3-82 |