The V(H )gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus

In systemic lupus erythematosus (SLE) it has been hypothesized that self-reactive B cells arise from virgin B cells that express low-affinity, nonpathogenic germline V genes that are cross-reactive for self and microbial antigens, which convert to high-affinity autoantibodies via somatic hypermutati...

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Detalles Bibliográficos
Autores principales: Fraser, Nicola LW, Rowley, Gary, Field, Max, Stott, David I
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165037/
https://www.ncbi.nlm.nih.gov/pubmed/12718755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165037/
https://www.ncbi.nlm.nih.gov/pubmed/12718755

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