Functional asymmetry in the lysyl-tRNA synthetase explored by molecular dynamics, free energy calculations and experiment

BACKGROUND: Charging of transfer-RNA with cognate amino acid is accomplished by the aminoacyl-tRNA synthetases, and proceeds through an aminoacyl adenylate intermediate. The lysyl-tRNA synthetase has evolved an active site that specifically binds lysine and ATP. Previous molecular dynamics simulatio...

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Detalles Bibliográficos
Autores principales: Hughes, Samantha J, Tanner, Julian A, Hindley, Alison D, Miller, Andrew D, Gould, Ian R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165585/
https://www.ncbi.nlm.nih.gov/pubmed/12787471
http://dx.doi.org/10.1186/1472-6807-3-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165585/
https://www.ncbi.nlm.nih.gov/pubmed/12787471
http://dx.doi.org/10.1186/1472-6807-3-5

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