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Population Pharmacokinetics of Artesunate and Dihydroartemisinin following Intra-Rectal Dosing of Artesunate in Malaria Patients
BACKGROUND: Intra-rectal artesunate has been developed as a potentially life-saving treatment of severe malaria in rural village settings where administration of parenteral antimalarial drugs is not possible. We studied the population pharmacokinetics of intra-rectal artesunate and the relationship...
Autores principales: | Simpson, Julie A, Agbenyega, Tsiri, Barnes, Karen I, Perri, Gianni Di, Folb, Peter, Gomes, Melba, Krishna, Sanjeev, Krudsood, Srivicha, Looareesuwan, Sornchai, Mansor, Sharif, McIlleron, Helen, Miller, Raymond, Molyneux, Malcolm, Mwenechanya, James, Navaratnam, Visweswaran, Nosten, Francois, Olliaro, Piero, Pang, Lorrin, Ribeiro, Isabela, Tembo, Madalitso, van Vugt, Michele, Ward, Steve, Weerasuriya, Kris, Win, Kyaw, White, Nicholas J |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1664603/ https://www.ncbi.nlm.nih.gov/pubmed/17132053 http://dx.doi.org/10.1371/journal.pmed.0030444 |
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