Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells

Oligonucleotide-mediated gene targeting is emerging as a powerful tool for the introduction of subtle gene modifications in mouse embryonic stem (ES) cells and the generation of mutant mice. However, its efficacy is strongly suppressed by DNA mismatch repair (MMR). Here we report a simple and rapid...

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Detalles Bibliográficos
Autores principales: Aarts, Marieke, Dekker, Marleen, de Vries, Sandra, van der Wal, Anja, te Riele, Hein
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1669774/
https://www.ncbi.nlm.nih.gov/pubmed/17142234
http://dx.doi.org/10.1093/nar/gkl896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1669774/
https://www.ncbi.nlm.nih.gov/pubmed/17142234
http://dx.doi.org/10.1093/nar/gkl896

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