Replication in mammalian cells recapitulates the locus-specific differences in somatic instability of genomic GAA triplet-repeats

Friedreich ataxia is caused by an expanded (GAA·TTC)(n) sequence in intron 1 of the FXN gene. Small pool PCR analysis showed that pure (GAA·TTC)(44+) sequences at the FXN locus are unstable in somatic cells in vivo, displaying both expansions and contractions. On searching the entire human and mouse...

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Detalles Bibliográficos
Autores principales: M. Rindler, Paul, Clark, Rhonda M., Pollard, Laura M., De Biase, Irene, Bidichandani, Sanjay I.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1669776/
https://www.ncbi.nlm.nih.gov/pubmed/17142224
http://dx.doi.org/10.1093/nar/gkl846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1669776/
https://www.ncbi.nlm.nih.gov/pubmed/17142224
http://dx.doi.org/10.1093/nar/gkl846

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