Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades

A hallmark of protein kinase/phosphatase cascades, including mitogen-activated protein kinase (MAPK) pathways, is the spatial separation of their components within cells. The top-level kinase, MAP3K, is phosphorylated at the cell membrane, and cytoplasmic kinases at sequential downstream levels (MAP...

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Detalles Bibliográficos
Autores principales: Markevich, Nick I, Tsyganov, Mikhail A, Hoek, Jan B, Kholodenko, Boris N
Formato: Texto
Lenguaje:English
Publicado: 2006
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1682027/
https://www.ncbi.nlm.nih.gov/pubmed/17102806
http://dx.doi.org/10.1038/msb4100108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1682027/
https://www.ncbi.nlm.nih.gov/pubmed/17102806
http://dx.doi.org/10.1038/msb4100108

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