Solution structure of a purine rich hexaloop hairpin belonging to PGY/MDR1 mRNA and targeted by antisense oligonucleotides

A preferential target of antisense oligonucleotides directed against human PGY/MDR1 mRNA is a hairpin containing a stem with a G•U wobble pair, capped by the purine-rich (5′)r(GGGAUG)(3′) hexaloop. This hairpin is studied by multidimensional NMR and restrained molecular dynamics, with special emphas...

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Detalles Bibliográficos
Autores principales: Joli, Flore, Bouchemal, Nadia, Laigle, Alain, Hartmann, Brigitte, Hantz, Edith
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1694020/
https://www.ncbi.nlm.nih.gov/pubmed/17041234
http://dx.doi.org/10.1093/nar/gkl617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1694020/
https://www.ncbi.nlm.nih.gov/pubmed/17041234
http://dx.doi.org/10.1093/nar/gkl617

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