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Solution structure of a purine rich hexaloop hairpin belonging to PGY/MDR1 mRNA and targeted by antisense oligonucleotides
A preferential target of antisense oligonucleotides directed against human PGY/MDR1 mRNA is a hairpin containing a stem with a G•U wobble pair, capped by the purine-rich (5′)r(GGGAUG)(3′) hexaloop. This hairpin is studied by multidimensional NMR and restrained molecular dynamics, with special emphas...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1694020/ https://www.ncbi.nlm.nih.gov/pubmed/17041234 http://dx.doi.org/10.1093/nar/gkl617 |