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Sensitivity to endothelin-1 is decreased in isolated livers of endothelial constitutive nitric oxide synthase knockout mice

BACKGROUND: Hepatic sinusoidal resistance is regulated by vasoactive factors including endothelin-1 (ET-1) and nitric oxide (NO). In the absence of NO, vasoconstrictor response to endothelin is expected to predominate. Therefore, we hypothesized sensitivity to endothelin to be increased in mice lack...

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Detalles Bibliográficos
Autores principales: De Gottardi, Andrea, Biecker, Erwin, Koshy, Abraham, Bohler, Dieter, Shaw, Sidney, Sägesser, Hans, Reichen, Jürg
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1697821/
https://www.ncbi.nlm.nih.gov/pubmed/17147823
http://dx.doi.org/10.1186/1476-5926-5-9