Use of thermolytic protective groups to prevent G-tetrad formation in CpG ODN type D: structural studies and immunomodulatory activity in primates

CpG oligodeoxynucleotides (ODN) show promise as immunoprotective agents and vaccine adjuvants. CpG ODN type D were shown to improve clinical outcome in rhesus macaques challenged with Leishmania major. These ODN have a self-complementary core sequence and a 3′ end poly(G) track that favors G-tetrad...

Descripción completa

Detalles Bibliográficos
Autores principales: Puig, Montserrat, Grajkowski, Andrzej, Boczkowska, Malgorzata, Ausín, Cristina, Beaucage, Serge L., Verthelyi, Daniela
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702498/
https://www.ncbi.nlm.nih.gov/pubmed/17130156
http://dx.doi.org/10.1093/nar/gkl867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702498/
https://www.ncbi.nlm.nih.gov/pubmed/17130156
http://dx.doi.org/10.1093/nar/gkl867

Ejemplares similares