c-Fos is required for excision repair of UV-light induced DNA lesions by triggering the re-synthesis of XPF

Cells deficient in c-Fos are hypersensitive to ultraviolet (UV-C) light. Here we demonstrate that mouse embryonic fibroblasts lacking c-Fos (fos−/−) are defective in the repair of UV-C induced DNA lesions. They show a decreased rate of sealing of repair-mediated DNA strand breaks and are unable to r...

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Detalles Bibliográficos
Autores principales: Christmann, Markus, Tomicic, Maja T., Origer, Judith, Aasland, Dorthe, Kaina, Bernd
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702502/
https://www.ncbi.nlm.nih.gov/pubmed/17130154
http://dx.doi.org/10.1093/nar/gkl895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702502/
https://www.ncbi.nlm.nih.gov/pubmed/17130154
http://dx.doi.org/10.1093/nar/gkl895

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