Versatile modeling and optimization of fed batch processes for the production of secreted heterologous proteins with Pichia pastoris

BACKGROUND: Secretion of heterologous proteins depends both on biomass concentration and on the specific product secretion rate, which in turn is not constant at varying specific growth rates. As fed batch processes usually do not maintain a steady state throughout the feed phase, it is not trivial...

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Detalles Bibliográficos
Autores principales: Maurer, Michael, Kühleitner, Manfred, Gasser, Brigitte, Mattanovich, Diethard
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1712348/
https://www.ncbi.nlm.nih.gov/pubmed/17156474
http://dx.doi.org/10.1186/1475-2859-5-37

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1712348/
https://www.ncbi.nlm.nih.gov/pubmed/17156474
http://dx.doi.org/10.1186/1475-2859-5-37

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