X-ray crystallographic study of DNA duplex cross-linking: simultaneous binding to two d(CGTACG)(2) molecules by a bis(9-aminoacridine-4-carboxamide) derivative

Acridine-4-carboxamides form a class of known DNA mono-intercalating agents that exhibit cytotoxic activity against tumour cell lines due to their ability to inhibit topoisomerases. Previous studies of bis-acridine derivatives have yielded equivocal results regarding the minimum length of linker nec...

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Detalles Bibliográficos
Autores principales: Hopcroft, Nicholas H., Brogden, Anna L., Searcey, Mark, Cardin, Christine J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751537/
https://www.ncbi.nlm.nih.gov/pubmed/17145714
http://dx.doi.org/10.1093/nar/gkl930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751537/
https://www.ncbi.nlm.nih.gov/pubmed/17145714
http://dx.doi.org/10.1093/nar/gkl930

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